antiangiogenic agent — TargetMol Chemicals

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Search Results for " antiangiogenic agent "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T79364	Antiangiogenic agent 4		Akt
	Compound 3b, an antiangiogenic agent, inhibits Akt phosphorylation in both HFF and HUVEC cells and is utilized in cancer research [1].		Akt
T62931	Antiangiogenic agent 2
	Antiangiogenic agent 2 (compound 3b) is a potent inhibitor of thymidine phosphorylase (IC50: 39.71 μM) and exhibits anti-angiogenic effects.
T72363	Antiangiogenic agent 3
	Antiangiogenic agent 3 is a potent inhibitor of human umbilical vein endothelial cells (HUVEC), effectively blocking HUVEC migration and chemotactic motilities. Additionally, it suppresses the gene expression of Src, cdc...
T16545	Pivanex	Pivalyloxymethyl butyrate,AN-9	Apoptosis , HDAC , Bcr-Abl
	Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.		Apoptosis , HDAC , Bcr-Abl
T1178	Temozolomide	NSC 362856,TZM,CCRG 81045,TMZ	Apoptosis , DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy
	Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic activity, and also induces apoptosis and autophagy.
T1608	ADH-1 trifluoroacetate	Exherin trifluoroacetate	Dehydrogenase
	ADH-1 trifluoroacetate (Exherin trifluoroacetate) is a cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-c...		Dehydrogenase
T6695	Tasquinimod	ABR-215050	HDAC
	Tasquinimod (ABR-215050) is a quinoline-3-carboxamide linomide analog with antiangiogenic and potential antineoplastic activities. Tasquinimod has been shown to decrease blood vessel density but the exact mechanism of ac...		HDAC
T15616	JNJ-10198409	JNJ-10198409	PDGFR
	JNJ- 10198409 is a relatively selective and ATP competitive PDGF-RTK inhibitor (IC50=2 nM). JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM). It is a dual-mechanism, ant...		PDGFR
T70609	Bisnafide mesylate
	Bisnafide is a Naphthalimide Analogue that acts as DNA intercalator and topo II inhibitor. It is also an antiangiogenic agent. Antiangiogenic agents can normalize tumor vessels and promote the delivery of cytotoxic agent...
T25159	Bisnafide	DMP 840
	Bisnafide is a Naphthalimide Analogue that acts as a DNA intercalator and topo II inhibitor. It is also an antiangiogenic agent that can normalize tumor vessels and promote the delivery of cytotoxic agents to tumor sites...
T33281	Melflufen	Prodrug J-1, Melflufen, Melphalan flufenamide,Melphalan flufenamide,J 1,J1,J-1
	Melphalen fluoroaniline, also known as melphalen, J-1, or prodrug J-1, is a prodrug of melphalen, in which the alkylating agent melphalen is combined with fluoroaniline and has potential antitumor and antiangiogenic acti...
T70906	EHT-6706
	EHT-6706 is a novel microtubule-disrupting agent that targets the colchicine-binding site to inhibit tubulin polymerization. At low nM concentrations, EHT 6706 exhibits highly potent antiproliferative activity on more th...
T71204	Apatinib HC	Rivoceranib HCl,YN-968D1 HCl
	Apatinib, also known as Rivoceranib and YN-968D1, is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. The free-base form is also known...
T71180	Oglufanide disodium
	Oglufanide disodium is t he disodium salt of a synthetic form of a naturally-occurring dipeptide consisting of L-glutamic acid and L-tryptophan with potential antiangiogenic and potential immunomodulating activities. Ogl...
T70018	Apricoxib
	Apricoxib, also known as Benzenesulfonamide 42(4ethoxyphenyl)4methyl1Hpyrrol1yl, is an orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricox...
T9684	(Z)-Orantinib
	(Z)-Orantinib ((Z)-SU6668) is a potent, selective, orally active and ATP competitive inhibitor of Flk‐1/KDR, PDGFRβ, and FGFR1, with IC 50 s of 2.1, 0.008, and 1.2 μM, respectively. (Z)-Orantinib is a potent antiangiogen...
T80523	Azurin p28 peptide
	Azurin p28 peptide, a tumor-penetrating antitumor agent, stabilizes p53 by reducing its proteasomal degradation via the formation of a p28:p53 complex. It elicits apoptosis or cell cycle arrest and suppresses the growth ...

Compounds

Antiangiogenic agent 4

T79364

Synonym:

Target: Akt

Antiangiogenic agent 2

T62931

Synonym:

Target:

Antiangiogenic agent 3

Synonym: Pivalyloxymethyl butyrate,AN-9

Target: Apoptosis, HDAC, Bcr-Abl

Temozolomide

T1178

Synonym: NSC 362856,TZM,CCRG 81045,TMZ

Target: Apoptosis, DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy

ADH-1 trifluoroacetate

T1608

Synonym: Exherin trifluoroacetate

Target: Dehydrogenase

Synonym: JNJ-10198409

Synonym: Prodrug J-1, Melflufen, Melphalan flufenamide,Melphalan flufenamide,J 1,J1,J-1

Synonym: Rivoceranib HCl,YN-968D1 HCl

Cat No.	Product Name	Targets
T3S2027	Rubusoside	Others
	1. Rubusoside is a natural sweetener . 2. Rubusoside is a solubilizing agent with antiangiogenic and antiallergic properties.	Others
TMA1743	Ergosterol peroxide	ERK , VEGFR , p38 MAPK , Wnt/beta-catenin , Akt , JAK , CDK , JNK , STAT , Antifection
	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pr...

Natural Products

Target: ERK, VEGFR, p38 MAPK, Wnt/beta-catenin, Akt, JAK, CDK, JNK, STAT, Antifection

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00948	Endostatin Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Endostatin, an endogenous non‑glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP‑2 and MMP‑9, and cathepsins S, B and L. The N‑termi...

Endostatin Protein, Mouse, Recombinant (His)

TMPJ-00948

Species: Mouse

Expression System: Human Cells